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            PI-103 hydrochloride说明

            发布日期:2017-04-24   浏览次数:0
            核心提示:PI-103 hydrochloride是有效地PI3K/Akt and mTOR抑制剂,对重组PI3K同工型p110α和mTOR的IC50值分别为2 nM和30 nM。
            PI-103 hydrochloride是有效地PI3K/Akt and mTOR抑制剂,对重组PI3K同工型p110α和mTOR的IC50值分别为2 nM和30 nM。
            产品描述:Mizoribine(NSC 289637; HE 69; β-Bredinin) is an immunosuppressive agents (IC50=100 uM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. IC50 Value: Target: IMPDH in vitro: Unlike azathioprine, Mizoribine is not taken up by nucleic acids in the cell. Instead, after phosphorylation MZR-5 -monophosphate inhibits GMP synthesis by the antagonistic blocking of IMPDH (Ki = 10(-8)M) and GMP- synthetase (Ki =10(-5) M) [1]. Pretreatment of cells with MZR partially, but significantly, attenuates the expression of monocyte chemoattractant protein (MCP)-1 mRNA and protein, wheras the poly IC-induced expressions for the other functional molecules, such as CCL5, fractalkine and IL-8 were not influenced by MZR treatment [2]. in vivo:MZR 150 mg was administered once a day. After 6 months, the remission rate was 72.7% (2 subjects achieved complete remission, and 9 partial remission). After 3 and 6 months, significant reductions (p < 0.01) were obtained in 24-h pr


            公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。
            MCE 对每批产品都进行严格的LCMS和NMR检验,其产品已被全球近万名客户广泛使用并发表大量文章、专利;
            MCE 定期增加各领域热门抑制剂、激动剂,不断扩增已有化合物库,以满足最新的科研需求;
            数千种产品在上海有充足备货,24-48小时内送达客户;
            大量产品提供免费试用装; 已为全球多个知名企业、院校构建各种定制型化合物库。

            产品链接:


            Purity:98%
            MWt:384.8163
            Formula:C19H17ClN4O3
            SMILES:OC1=CC(C2=NC3=C(OC4=C3C=CC=N4)C(N5CCOCC5)=N2)=CC=C1.[H]Cl
            Pathway:PI3K/Akt/mTOR;
            Mechanisms:mTOR; PI3K;
            Research Area:Cancer
            电话:
            网址: www.MedChemExpress.cn
            地址: 上海市浦东新区蔡伦路720号2号楼3层
             
            关键词: PI-103 hydrochloride
             
             
            

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