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            ML204说明

            发布日期:2017-04-24   浏览次数:0
            核心提示:ML204是TRPC4/C5离子通道新型高效抑制剂。
            ML204是TRPC4/C5离子通道新型高效抑制剂。
            产品描述:Valacyclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Target: HSV Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. VACV uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 +/- 0.06 mM and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro . For treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valac


            公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。
            MCE 对每批产品都进行严格的LCMS和NMR检验,其产品已被全球近万名客户广泛使用并发表大量文章、专利;
            MCE 定期增加各领域热门抑制剂、激动剂,不断扩增已有化合物库,以满足最新的科研需求;
            数千种产品在上海有充足备货,24-48小时内送达客户;
            大量产品提供免费试用装; 已为全球多个知名企业、院校构建各种定制型化合物库。

            产品链接:


            Purity:98%
            MWt:226.3168
            Formula:C15H18N2
            SMILES:CC1=CC(N2CCCCC2)=NC3=CC=CC=C13
            Pathway:Membrane Transporter/Ion Channel;
            Mechanisms:TRP Channel;
            Research Area:Neurological Disease
            电话:
            网址: www.MedChemExpress.cn
            地址: 上海市浦东新区蔡伦路720号2号楼3层
             
            关键词: ML204
             
             
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