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          Ruboxistaurin说明

          发布日期:2017-04-23   浏览次数:0
          核心提示:Ruboxistaurin hydrochlorid是蛋白激酶C的抑制剂,是PKCβI 和 PKCβII竞争性可逆的抑制剂,IC50分别是4.7 nM和5.9 nM.
          Ruboxistaurin hydrochlorid是蛋白激酶C的抑制剂,是PKCβI 和 PKCβII竞争性可逆的抑制剂,IC50分别是4.7 nM和5.9 nM.
          产品描述:Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. IC50 value: Target: NAT10 inhibitor Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.


          公司介绍:MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库,总部位于美国新泽西,分别在瑞典和上海设有欧洲区子公司和亚洲区总代理,营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商, 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域,PI3K、MAPK等近千个细分靶点,超过4000个活性小分子化合物现货,以及GPCR、API、离子通道等超过20种不同类型的化合物库,同时提供从毫克到千克的专业定制合成服务。
          MCE 对每批产品都进行严格的LCMS和NMR检验,其产品已被全球近万名客户广泛使用并发表大量文章、专利;
          MCE 定期增加各领域热门抑制剂、激动剂,不断扩增已有化合物库,以满足最新的科研需求;
          数千种产品在上海有充足备货,24-48小时内送达客户;
          大量产品提供免费试用装; 已为全球多个知名企业、院校构建各种定制型化合物库。

          产品链接:


          Purity:98%
          MWt:505.0079
          Formula:C28H29ClN4O3
          SMILES:O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[C@H](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.[H]Cl
          Pathway:Epigenetics; TGF-beta/Smad;
          Mechanisms:PKC;
          Research Area:Cancer
          电话:
          网址: www.MedChemExpress.cn
          地址: 上海市浦东新区蔡伦路720号2号楼3层
           
          关键词: Ruboxistaurin
           
           
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